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Nano Emulsions

Nutraceuticals

Manufacturing of functional beverage with non-surfactant-based emulsion (Vitamin Tree Oil, nano-emulsion).

The intake and bioavailability of functional foods are directly related to the product’s effectiveness. As a result, many food companies
are attempting to enhance the bioavailability of functional ingredients. Generally, poorly soluble and insoluble compounds and highly lipophilic compounds are not well absorbed by the gastrointestinal mucosa, resulting in low bioavailability. On top of that,
even water-soluble compounds can have low bioavailability due to ingredients’ difficulties in passing through lipid-based barriers
such as cell membranes to reach the body's interior.

Bioavailability and absorption level can be enhanced by reducing the size of the formulation containing functional ingredients to very small nano-sized particles (emulsion). Much smaller ingredient particles are more easily absorbed into the body through various pathways. Furthermore, smaller surface areas will reduce the total dosage (intake amount) as smaller dosages can yield high
absorption rates, ultimately reducing potential side effects.

Manufacturing
of nano-emulsion with non- surfactant-based Vitamin Tree (Seabuckthorn) Oil

  • Ingredients : Vitamin Tree (Hippophae rhamnoides) Oil 1%
  • Solvent : Purified water, surfactant-free
  • Production of functional beverage by surfactant-free emulsion.

Dispersion stability evaluation

  • Test method : Cosmetic stability testing guidelines (long-term preservation/accelerated testing conditions - refrigerated product)
  • Temperature : 25 ± 2 ℃
  • Relative humidity : 60 ± 5 %
  • Evaluation period : 30 days
  • Evaluation : Maintained dispersion stability (long-term preservation, accelerated testing)

After 30 days (long-term preservation/accelerated testing).

분산 균일성 평가

비타민나무 오일 에멀젼 (1%) 현미경 사진

분산 균일성 측정 Ⅰ

  • 측정기기 Nikon Eclipse 50i (편광필터 / Olympus, U-PO)
    Sometech SV-35 Video Microscope
  • 평가 : 입자크기, 60 ~ 900 nm 에멀젼 (1㎛ 이하 균일한 입자분포 구성)

비타민나무 오일 에멀젼 (1%) 입도 분석

분산 균일성 측정II
  • 측정기기 HORIBA Laser Scattering Particle Size
    Distribution Analyzer LA-960
  • 평가 : 입자크기, 60 ~ 900 nm 에멀젼 (1㎛ 이하 균일한 입자분포 구성)